达尔巴万辛在骨和关节感染中的作用:系统性审查
Sofia Lovatti1, Giorgio Tiecco1, Alice Mulé1
1Unit of Infectious and Tropical Diseases, Department of Clinical and Experimental Sciences, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Pharmaceuticals (Basel, Switzerland)
|July 29, 2023
概括
达尔巴万辛 (DBV) 有效治疗困难的骨关节感染,三剂量疗法显示出最高的成功率. 最佳的结果与与这种长效抗生素一起进行手术管理有关.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 整形外科 整形外科 整形外科
背景情况:
- 达尔巴万辛 (DBV) 已被批准用于治疗急性细菌性皮肤感染,但在各种部位用于治疗格拉姆阳性细菌感染的非标签药物.
- 骨关节 (OA) 感染,包括骨髓炎,脊髓炎和败血性关节炎,具有挑战性治疗.
- 目前的临床实践缺乏针对OA感染的标准化DBV剂量方案.
研究的目的:
- 系统地审查有关达尔巴万辛 (DBV) 用于骨关节 (OA) 感染的服用时间表的文献.
- 描述与不同DBV剂量方案在OA感染中相关的结果.
主要方法:
- 根据PRISMA指南进行了系统的文献审查.
- 在PubMed和Cochrane控制试验中进行了对OA感染中DBV的同行评审文章的搜索.
- 包括的研究包括患有骨髓炎,脊髓炎和败血性关节炎的患者.
主要成果:
- 该审查包括23项涉及450名患者的研究;金黄色葡萄球菌是最常见的病原体.
- 总体而言,79.3%的患者获得了成功的DBV治疗.
- 每周服用三剂量DBV的治疗方案显示成功率为92.3%,而服用两剂以下或四剂以上的治疗方案的失败率更高 (27.8%).
结论:
- 达尔巴万辛 (DBV) 是骨关节 (OA) 感染的有效治疗选择.
- 观察到最有利的结果是三剂量DBV疗法与适当的手术管理相结合.
- 虽然没有确定的剂量计划,但DBV为管理OA感染提供了可行的治疗选择.
关键词:
德比维 (DBV) 是一个多元化公司.格拉姆阳性菌种.系统性审查 系统性审查关节炎是一种关节炎.骨头 骨头 骨头 骨头达尔巴万辛 (达尔巴万辛) 是一个关节 关节 关节 关节骨关节感染 骨关节感染骨质炎是一种骨质炎.审查 审查 审查 审查 审查 审查脊髓瘤发生的原因是更多相关视频
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