含有固定和精油的益生菌配方可改善大鼠SIBO诱导的肠道失调症
Ismail Aslan1,2,3, Leyla Tarhan Celebi2,3, Hulya Kayhan4
1Department of Pharmaceutical Technology, Hamidiye Faculty of Pharmacy, University of Health Sciences, İstanbul 34668, Turkey.
Pharmaceuticals (Basel, Switzerland)
|July 29, 2023
概括
这项研究表明,一种新的益生菌和油混合物有效地治疗小肠细菌过度生长 (SIBO) 在老鼠中. 治疗逆转了消化损伤和减少了炎症,这表明SIBO的未来治疗潜力.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 肠道微生物群失生症与各种肠道和代谢疾病有关,包括刺激性肠综合征 (IBS) 和小肠细菌过度生长 (SIBO).
- SIBO的定义是小肠中的细菌数量增加,影响整体健康.
- 目前用于SIBO的抗生素治疗方法往往不足,这凸显了对替代疗法的需要.
研究的目的:
- 评估一种新型益生菌配方与子和精油结合在SIBO的小鼠模型中的治疗疗效.
- 调查这种联合治疗对肠道微生物群失调和相关炎症标志物的影响.
主要方法:
- 建立了一个基于失调的SIBO大鼠模型.
- 鼠被用子油,薄荷--帕丘利精油和益生菌混合物的组合治疗.
- 组织学分析和TNF-α水平的测量被用来评估治疗效果.
主要成果:
- 油加益生菌混合方案显著降低了TNF-α水平,与患病的老鼠和那些被单独成分治疗的老鼠相比.
- 组织学检查显示,在接受治疗的老鼠中,小结构的恢复,线粒细胞数的增加,以及炎症细胞透的减少.
- 治疗导致炎症反应的回归和杯状细胞的增加,表明肠道健康得到改善.
结论:
- 结合益生菌和油处理有效地改善了SIBO诱导的老鼠损伤.
- 这种方法显示出显著的抗炎作用,并恢复了消化系统的完整性.
- 这些发现表明,这种新的治疗策略对未来的SIBO疗法具有前景.
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