基于交联粉的含有大麻二醇的纳米颗粒:抗炎活性和改善鼻至脑输送
Ilya Eydelman1, Na'ama Zehavi2, Valeria Feinshtein1
1Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Be'er Sheva 8410501, Israel.
Pharmaceutics
|July 29, 2023
概括
新的粉纳米颗粒通过鼻内注射有效地将大麻素 (CBD) 输送到大脑. 这种新的系统通过减少炎症和改善CBD大脑水平来治疗神经退行性疾病具有前景.
科学领域:
- 神经科学是一个神经科学.
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 大麻二醇 (CBD) 具有与神经退行性疾病相关的抗炎性质.
- 对于治疗应用来说,CBD对大脑的有效输送仍然是一个重大挑战.
研究的目的:
- 开发和评估一种新的粉纳米粒子系统,以增强CBD鼻内输送到大脑.
- 为了在体外评估含有CBD的纳米颗粒的抗炎疗效.
主要方法:
- 含有CBD的粉纳米颗粒使用纳米沉方法与迪瓦尼林交叉连接进行了合成.
- 纳米粒子的表征包括电子显微镜 (平均尺寸为200nm).
- 在体外的抗炎活性被测试在脂聚糖诱导的炎症BV2微质细胞上,测量氧化和IL-6水平.
主要成果:
- 与CBD溶液相比,通过鼻内注射含有CBD的粉纳米颗粒可以达到较高的CBD脑度.
- 这些纳米颗粒在BV2细胞中表现出低毒性.
- 含有CBD的纳米颗粒显著降低了氧化和IL-6的产生,相当于葡萄糖皮质体治疗.
结论:
- 基于粉的纳米颗粒提供了一个可行的平台,可以有效地将CBD通过鼻腔输送到中枢神经系统.
- 这种方法有可能用于治疗与神经退行性疾病相关的神经炎症状况.
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