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Updated: Jun 24, 2026

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开发一种酒精稀释-化方法,用于制备具有更好的存储稳定性的mRNA-LNP

Daiki Shirane1, Hiroki Tanaka2, Yu Sakurai2

  • 1Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-0856, Japan.

Pharmaceutics
|July 29, 2023
PubMed
概括

携带信使RNA (mRNA) 的冷干燥脂质纳米颗粒 (LNP) 可以在4°C下存储超过4个月,从而提高mRNA-LNP疫苗的稳定性和可访问性.

关键词:
结干燥 结干燥 结干燥脂质纳米颗粒是一种纳米粒子.提供mRNA的交付.储存中的稳定性.

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RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...