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一个柔软的皮肤粘合剂 (SSA) 贴片用于延长释放皮尔芬尼在烧伤中的伤口
Eugene P Chung1,2, Jesse Q Nguyen1, Tobias Tellkamp-Schehr3
1Combat Wound Care Group, US Army Institute of Surgical Research, JBSA, Fort Sam Houston, TX 78234, USA.
Pharmaceutics
|July 29, 2023
概括
一种新型的药物-在-矩阵贴片提供皮尔芬尼 (Pf) 防止伤口痕. 这种柔软的皮肤粘合贴可以减少皮肤脱落和炎症,显示稳定性和规模制造的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 伤口治愈研究研究 伤口治愈研究
- 药物输送系统 药物输送系统
背景情况:
- 深度部分厚度烧伤经常导致过度缩性痕和收缩,形成后治疗选择有限.
- 皮尔芬尼 (Pf) 是一种抗炎和抗纤维素剂,具有防止烧伤痕的潜力.
研究的目的:
- 开发和评估一种药物在矩阵贴片,用于为期几天的皮尔费尼 (Pf) 给烧伤.
- 评估贴片在预防痕方面的有效性及其安全性.
主要方法:
- 构建了一个多层贴片,包括软皮粘合剂 (SSA) 层,含有Pf的烯酸共聚合物药物矩阵和聚氨支持.
- 使用扫描电子显微镜 (SEM) 评估贴片性能,用于皮肤剥离,体外药物释放,体外皮肤透以及猪烧伤模型的体内研究.
- 在长期和加速储存条件下评估了补丁稳定性,并开发了扩大规模的制造工艺.
主要成果:
- 与传统的粘合贴相比,SSA层显著减少了皮肤脱落.
- 在体外和体外研究证实了药物释放动力学和透,没有SSA的干扰.
- 通过贴片连续多天的Pf输送减少了猪烧伤中的促炎生物标志物,证明了治疗潜力.
结论:
- 开发的Pirfenidone药物-在-矩阵贴片与SSA层提供了一个有希望的策略,以防止烧伤伤痕.
- 该贴片表现出良好的稳定性,易于应用/移除,减少皮肤创伤,具有可扩展制造的潜力.
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