局部化药物输送系统:关于头部和部状细胞癌的治疗选择的最新情况
Arvind Hariharan1, Simon D Tran1
1McGill Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, 3640 University Street, Montreal, QC H3A 0C7, Canada.
Pharmaceutics
|July 29, 2023
概括
局部化药物递送系统为治疗头角状细胞癌 (HNSCC) 和辐射诱导的口症提供了一种有前途的方法. 这些系统旨在通过将药物直接输送到受影响的组织,减少副作用并改善患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 药物输送系统 药物输送系统
- 癌症治疗方法 癌症治疗方法
背景情况:
- 头部和部状细胞癌 (HNSCC) 是全球流行的一种癌症,目前的治疗方法包括手术,放射治疗,化疗和免疫治疗.
- 对HNSCC和辐射诱导的异位静止症药物的全身服药通常会导致显著的副作用,影响患者的生活质量.
- 局部化药物输送系统 (LDDS) 正在成为缓解这些毒性的战略.
研究的目的:
- 审查当前和潜在的局部药物递送系统 (LDDS) 用于头部和部状细胞癌 (HNSCC) 治疗.
- 探索LDDS在管理放射治疗引起的损伤,如口症的应用.
- 评估LDDS在改善患者体验和减少治疗相关毒性方面的潜力.
主要方法:
- 对HNSCC局部药物输送系统的现有文献的审查.
- 探索通过皮肤和膜输送药物输送路径以进行局部管理.
- 在HNSCC治疗中分析与LDDS相关的优势和挑战.
主要成果:
- LDDS提供了一种有针对性的方法,有可能减少全身暴露和相关的副作用.
- 透菌和透皮途径是局部药物输送到头部和部区域的关键方式.
- LDDS在直接治疗癌症和管理诸如口症等副作用方面都表现有前途.
结论:
- 局部化药物输送系统在管理HNSCC及其与治疗相关的并发症方面取得了重大进展.
- 需要进一步的研究和开发来克服障碍,并充分实现LDDS的潜力,以改善患者的治疗结果.
- LDDS有望提供更有效,更为患者友好的癌症治疗,并将毒性降至最低.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.5K
11:51Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
30.6K
相关概念视频
Drug Delivery: Miscellaneous Routes
383
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
383
Drug Delivery: Overview
323
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
323
