酸盐涂层SLN:一种潜在的系统,用于眼部输送甲尼达
Simise S Sikhondze1, Pedzisai A Makoni2, Roderick B Walker1
1Division of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Makhanda 6140, South Africa.
Pharmaceutics
|July 29, 2023
概括
新的酸盐涂层酸盐 (MTZ) 装载的固体脂质纳米颗粒 (SLN) 提供了改善的眼部输送. 这种每天一次的配方增强了前角膜保留和眼睛的可用性,可能减少剂量频率.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 眼部药物输送 眼部药物输送
背景情况:
- 眼科药物输送面临着住院时间较短的挑战,导致频繁的剂量和不坚持.
- 甲尼达 (MTZ) 对于治疗眼部感染至关重要,但其传递需要增强才能持续有效.
研究的目的:
- 开发和表征酸盐涂层的含有甲基醇的固体脂质纳米粒子 (CS-MTZ-SLNs),用于每天一次的眼部注射.
- 评估开发的纳米载体的粘粘性,体外释放和稳定性,以改善眼睛的可用性.
主要方法:
- 装有美特罗尼达的固体脂质纳米颗粒 (SLN) 通过化乳化和超声波制造.
- 通过机械,SLN被涂上素 (CS);配方使用了Gelucire® 48/16,Transcutol® HP和Tween® 20.
- 特性包括颗粒大小,多分散性指数,Zeta潜力,捕获效率,负载能力,pH,度和体外粘膜粘合.
主要成果:
- 优化的CS-MTZ-SLNs表现出稳定的纳米尺寸粒子,具有理想的物理化学特性.
- 在体外粘附性研究表明,由于改善前角膜保留,增加了眼睛的可用性.
- 该配方显示了中的持续释放,表明可能减少剂量频率.
结论:
- 含有基托桑涂层的甲化醇的固体脂质纳米颗粒代表了增强眼部药物输送的有前途的战略.
- 开发的纳米载体提供了每天一次剂量的潜力,改善了患者的坚持和治疗结果.
- 在治疗眼部感染方面,CS-MTZ-SLNs具有显著的临床应用潜力.
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