基于模型的精确剂量定量软件工具用于剂量方案个性化:一个范围审查
Paula Del Valle-Moreno1, Paloma Suarez-Casillas1, Marta Mejías-Trueba1,2
1Department of Pharmacy, University Hospital Virgen del Rocío, 41013 Seville, Spain.
本综述总结了模型信息精确剂量 (MIPD) 软件的证据,这是治疗药物监测 (TDM) 的重要工具. 该研究确定了18个可用的MIPD软件,强调了标准化和验证的必要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 计算生物学 计算生物学
背景情况:
- 治疗药物监测 (TDM) 依赖于药物动力学名图,方程和软件.
- 基于模型的精确剂量 (MIPD) 软件通过知识整合和统计分析实现了个性化剂量.
- 尽管在临床上广泛使用,但MIPD软件的证据仍然有限.
研究的目的:
- 系统地审查和综合MIPD软件工具的现有证据.
- 帮助用户识别,评估和选择合适的MIPD软件.
- 提供目前可用的MIPD软件的全面概述.
主要方法:
- 在主要数据库 (MEDLINE,EMBASE,OpenAIRE,BASE) 进行了广泛的电子文献搜索,截至2022年7月.
- 遵循PRISMA-ScR (系统性审查的首选报告项目和范围审查的元分析扩展) 的指导方针.
- 纳入标准集中在详细介绍临床实践,研究或建模软件开发的研究上.
主要成果:
- 二十八个软件工具被确定为MIPD软件,10个目前无法使用.
- 对于剩下的18个可访问的MIPD软件,提供了详细的描述.
- 所有审查的MIPD软件都使用贝叶斯统计方法来估计药物暴露,大多数提供默认人口模型 (例外:NONMEN).
结论:
- 药物动力学软件,特别是MIPD工具,对于有效的TDM越来越重要.
- 对MIPD软件的比较分析可以指导临床选择.
- 对MIPD软件的质量标准化和验证对于未来的开发和临床采用至关重要.
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