FRO对的有效性 的病原性
Jung-Eun Kim1, Hengmin Han2, Yinzhu Xu1
1Department of Science in Korean Medicine, College of Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Pharmaceutics
|July 29, 2023
概括
这项研究表明,发酵的Rhus verniciflua Stokes和Orostachys japonicus (FRO) 配方通过抑制Cutibacterium acnes (CA) 的生长,炎症和多余的脂质产生,有效地对抗. FRO证明了治疗和功能化品的潜力.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 是一种普遍的皮肤疾病,由皮脂增加,炎症和Cutibacterium acnes (CA) 繁殖驱动.
- 目前的治疗方法面临挑战,需要新的治疗方法.
研究的目的:
- 为了评估FRO的抗疗效,这是Rhus verniciflua Stokes和Orostachys japonicus的发酵配方.
- 调查FRO对关键病原因的机制,包括CA生长,炎症和脂质生成.
主要方法:
- 化学分析 (HPLC) 在FRO中确定了化合物.
- 在体外测试中评估了FRO对CA的抗菌活性,对活性氧物种的影响,炎症标志物 (iNOS,TNF-α,IL-6,STAT-3,NF-κB) 和刺激皮肤细胞 (HaCaT,THP-1,血红细胞,LNCaP) 的脂质生成 (FAS,SREBP-1).
主要成果:
- FRO含有酸,菲塞丁,奎尔塞丁和凯姆菲罗尔.
- FRO对CA表现出抗菌作用,并减少了LPS/CA诱导的活性氧物种和炎症.
- FRO抑制了类固醇激素诱导的脂质生成,并降低了血红细胞和前列腺癌细胞 (LNCaP) 中的关键调节剂.
结论:
- 通过向CA增殖,炎症和过度的脂质产生,FRO在缓解方面显示出显著的潜力.
- FRO是开发成功能化品或治疗的治疗剂的有希望的候选者.
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