基于水凝的药物输送系统对药物释放配置的平板电脑几何效应
Seyed-Farid Mohseni-Motlagh1, Roshanak Dolatabadi2,3, Majid Baniassadi1
1School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran 1439957131, Iran.
Pharmaceutics
|July 29, 2023
概括
平板电脑的几何形状显著影响药物释放率,影响药物输送系统的有效性. 了解几何因素可以预测药物释放概况,优化制药配方.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 计算建模 计算建模
背景情况:
- 控制药物释放率对于药物的最佳有效性和安全性至关重要.
- 识别影响药物释放特征的因素从输送系统是必不可少的.
- 平板电脑的几何形状是影响药物从口服输送系统释放的重要因素.
研究的目的:
- 为了研究平板电脑的几何如何影响药物释放概况.
- 为了确定单独的药片几何能否预测药物释放特征.
- 探索药片形状,尺寸和药物释放之间的关系.
主要方法:
- 从200个基于HPMC的片中模拟释放theophylline的药物,使用有限元素分析.
- 药片被分为八种常见的口服药片几何形状.
- 使用了统计分析,包括部分最小平方回归和ANOVA.
主要成果:
- 平板电脑的几何类型和尺寸可以预测药物释放特征,减少了广泛溶解测试的需要.
- 药物释放的准确预测不仅仅取决于与表面相关的变量.
- 药片几何形状的差异显著改变药物释放特征,即使药物剂量和配方成分相同.
- 释放时间在相同质量和材料但不同的几何形状的平板之间可以变化多达七倍.
结论:
- 平板电脑的几何形状是药物释放动力学的关键决定因素.
- 有限元分析与统计方法相结合,为预测药物释放提供了强大的工具.
- 药物片的设计应仔细考虑几何因素,以优化药物输送和治疗结果.
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