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Updated: Jul 20, 2025

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
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基于生理学的药理动力学建模用于预测患有脏功能障碍的癌症患者的伊马替尼布暴露:一个案例研究

Karen Rowland Yeo1, Oliver Hatley1, Ben G Small1

  • 1Certara UK Limited, Simcyp Division, Level 2-Acero, 1 Concourse Way, Sheffield S1 2BJ, UK.

Pharmaceutics
|July 29, 2023
PubMed
概括

这项研究使用了药理动力学模型来预测患有脏功能障碍的癌症患者的伊马替尼布暴露. 结果显示,α-1-酸糖蛋白水平和功能障碍严重程度会影响伊马替尼的药物暴露.

关键词:
在PBPK建模中使用PBPK模型.癌症 癌症 癌症 癌症 癌症包容性的包容性患有功能障碍的人.

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