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生物材料药物输送系统用于突出的眼部疾病
Avin Sapowadia1, Delaram Ghanbariamin1,2, Libo Zhou1
1Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Pharmaceutics
|July 29, 2023
概括
生物材料为与年龄相关的黄斑变性 (AMD) 和玻璃眼等疾病提供先进的眼部药物输送. 这些创新系统,包括植入物和纳米载体,显示出比传统治疗更好的疗效.
科学领域:
- 眼科和生物医学工程眼科和生物医学工程
- 专注于材料科学和眼睛疾病治疗的交叉点.
背景情况:
- 数以百万计的人患有眼部疾病,如与年龄相关的黄斑变性 (AMD) 和玻璃眼.
- 对这些疾病的传统治疗提出了挑战,影响了患者的治疗结果.
- 生物材料已经成为增强眼部药物输送的有希望的途径.
研究的目的:
- 审查用于眼部药物输送的主要生物材料类别.
- 讨论具体的例子,如植入物,纳米载体,微针和含有药物的隐形眼镜.
- 与传统方法相比,强调基于生物材料的方法的优势.
主要方法:
- 对眼部疾病的生物材料现有文献进行全面审查.
- 将生物材料分为主要类别的分类:眼部植入物,纳米载体,微针和含有药物的隐形眼镜.
- 分析临床试验数据以支持这些系统的疗效.
主要成果:
- 可生物降解和不可生物降解的眼部植入物提供持续的药物释放.
- 纳米载体,包括水凝,脂质体,纳米细胞,DNA启发的纳米颗粒和树枝状体,提供有针对性的交付.
- 微针和含有药物的隐形眼镜提供了最少的侵入性注射选择.
结论:
- 基于生物材料的眼部药物输送系统克服了传统治疗的局限性.
- 这些先进的系统显示出在改善AMD,玻璃眼瘤和其他眼部疾病的患者治疗结果方面显著的潜力.
- 临床证据支持在眼科中使用生物材料的有效性和优势.
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