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通过在PBPK模型中引入双相溶解数据来进行先进的体内预测

Alexander Denninger1,2, Tim Becker1, Ulrich Westedt3

  • 1Department of Pharmaceutical Technology, University of Bonn, Gerhard-Domagk-Strasse 3, 53121 Bonn, Germany.

Pharmaceutics
|July 29, 2023
PubMed
概括

生物相关的体外溶解与体生理基础药理动力学 (PBPK) 工具相结合,准确地预测药物的性能. 这种体外到体外抽取 (IVIVE) 方法通过预测体内药理动力学来增强配方开发.

关键词:
在 PBPK 建模中使用 PBPK 模型.双相溶解的两个阶段.药物产品 药物产品 药物产品支持配方,使得配方可以使用.溶解不良的药物 溶解不良的药物预测 预测 预测 预测

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