通过聚合诱导的自组合制备的多功能聚合体的合成
Hien Phan1,2, Robert Cavanagh3, Philippa Jacob2
1Institut de Chimie et des Matériaux Paris-Est (ICMPE), CNRS, University Paris Est Créteil, UMR 7182, 2 Rue Henri Dunant, 94320 Thiais, France.
Polymers
|July 29, 2023
概括
这项研究开发了用于药物输送,封装染料和响应刺激的多功能聚合体. 这些聚合体对有针对性的输送和受控释放有前途,证明了为先进疗法提供多功能平台.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 聚合体提供类似细胞的结构,用于封装各种药物.
- 开发具有可控释放的多功能聚合体对于先进的药物输送至关重要.
研究的目的:
- 创建多功能聚合体,整合着染料封装,刺激响应和表面修饰.
- 探索聚合物块长度对聚合体体形态和反应的影响.
- 合成叶酸功能化的聚合体,以潜在的向药物输送.
主要方法:
- 通过RAFT介导的聚合诱导自组合 (PISA) 来合成聚N-2-基甲胺) -b-聚N-二-甲乙烯胺).
- 用叶酸 (FA) 修改聚合体表面.
- 封装防水尼罗河红色 (NR) 和水友的硫5-NHS染料.
- 评估过氧化 (H2O2) 的反应性和药物释放动力学.
- 评估人类血中的聚合体稳定性和与MCF-7细胞的生物相容性.
主要成果:
- 聚合体形态 (球体与囊泡) 是受水友性块长度控制的,影响H2O2反应 (碎片化与聚合).
- 叶酸结合产生了FA功能化的聚合体,能够封装水性和水性染料.
- 载有NR的FA结合聚合体在暴露于H2O2.2时,证明了NR染料的受控释放.
- 开发出的聚合体在人体血中表现出稳定性,与癌细胞具有良好的生物相容性.
结论:
- 聚合诱导自组装 (PISA) 为多样化,响应性和功能性聚合体结构提供了一个可扩展的路线.
- 这些多功能聚合体显示出有针对性药物输送和受控释放应用的潜力.
- 一合成方法可以创建多部门和响应性药物输送系统.
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