随后的COVID-19 预防在COVID-19相关的淋巴细胞病变中
Therese Boyle1,2, Emma O'Lone2,3, Elaine Phua3
1Department of Clinical Immunology and Allergy, Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia.
Vaccines
|July 29, 2023
概括
接种COVID-19疫苗与抗GBM疾病的增加有关,但随后接种疫苗似乎是安全的. 抗体检测可以指导与疫苗相关的血球炎患者的预防需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 疫情继续影响全球健康,新出现的关于与感染和疫苗接种相关的球细胞疾病的报告.
- 已观察到抗GBM疾病 (球体隆炎) 的显著增加,需要对其管理进行进一步调查.
研究的目的:
- 在五年内审查抗GBM抗体检测率.
- 调查COVID-19疫苗接种后抗GBM疾病的发生率和结果.
- 在受影响的患者中评估后续COVID-19疫苗接种的安全性.
主要方法:
- 对抗GBM抗体检测率的回顾性审查.
- 随访三名患者的病例,活检证实了与COVID-19疫苗接种暂时相关的质膜炎.
- 评估COVID-19抗体水平和随后接种疫苗后的结果.
主要成果:
- 观察到显著的抗GBM抗体结果增加了三倍,其中25%与COVID-19疫苗接种有关.
- 随后对三名患者进行的COVID-19疫苗接种并没有导致不良反应或疾病复发.
- 在三名患者中,有两名患者表现出阳性COVID-19抗体水平,尽管免疫抑制.
结论:
- 观察到抗GBM抗体疾病发生率的增加可能与COVID-19疫苗接种有关.
- COVID-19抗体检测可能有助于确定预防要求.
- 替代性疫苗类型在与疫苗相关的淋巴结膜炎患者的随后接种疫苗时似乎是安全的.
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