使用主动监测,意大利的两中心观察性研究对疫苗的安全性进行了研究
Marco Montalti1, Zeno Di Valerio1, Raffaella Angelini2
1Unit of Hygiene, Department of Biomedical and Neuromotor Sciences, Public Health and Medical Statistics, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy.
Vaccines
|July 29, 2023
概括
意大利 意大利 意大利 意大利
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 世界卫生组织在2022年宣布麻疹成为公共卫生紧急情况.
- 意大利启动了一项针对高风险群体的疫苗接种活动,包括实验室人员和与男性发生性关系的男性.
- Imvanex/Jynneos疫苗是在两剂的初级系列中使用的,随着可选的增强剂.
研究的目的:
- 在意大利接种疫苗后调查免疫接种后不良事件 (AEFI).
- 评估系统和局部反应的发生率和严重程度.
- 为了评估Imvanex/Jynneos疫苗的短期耐受性.
主要方法:
- 基于参与者的积极监控在意大利的博洛尼亚和福利使用.
- 一个电子问卷从18岁及以上的接种疫苗的个人中收集了AEFI的数据.
- 描述性分析按症状类型和严重程度分层AEFI.
主要成果:
- 总共有191名参与者 (135名第一剂,50名第二剂,6名单剂) 被分析.
- 系统性反应报告了39.3% (第一剂) 和26.0% (第二剂),主要是喘息.
- 局部反应非常频繁 (97.0%的第一剂量, 100.0%的第二剂量),红色,胀和是常见的. 3/4级局部AEFI发生在16.8%和14.0%的参与者身上.
结论:
- 疫苗表现出良好的短期系统性耐受性.
- 较高的局部不良事件率需要监测,特别是在皮肤内给药时.
- 需要进一步的研究来了解当地AEFI的持久性和管理.
关键词:
根据AEFI的说法,AEFI是一个AEFI.现在,我已经有了Imvanex.吉尼诺斯 (Jynneos) 是一个名字.他们是MSMs,MSMs.不良事件不良事件不良事件的水是的水.药物监督和药物监督疫苗可以预防的疾病 疫苗可以预防的疾病疫苗监测 疫苗监测 疫苗监测 疫苗监测更多相关视频
08:13Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination
Published on: January 20, 2019
21.7K
11:28Analysis of Iophenoxic Acid Analogues in Small Indian Mongoose Herpestes Auropunctatus Sera for Use as an Oral Rabies Vaccination Biological Marker
Published on: May 31, 2019
5.9K
相关概念视频
01:19Pharmacovigilance
891
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
891
01:26Principles of Disease Surveillance
124
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
124
01:51Vaccinations
44.7K
Overview
44.7K
01:29Bias in Epidemiological Studies
353
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
353
00:42Cross-reactivity
31.3K
Overview
31.3K