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甲酸中断恢复了对抗SARS-CoV-2疫苗在不响应肝移植接收者的免疫性

Pierluigi Toniutto¹, Annarosa Cussigh², Sara Cmet²

¹Hepatology and Liver Transplantation Unit, Department of Specialized Medicine, Udine University Hospital, 33100 Udine, Italy.

|July 29, 2023

概括

在第四次SARS-CoV-2疫苗注射之前暂时停止甲酸 (MMF) 改善了肝移植接受者的抗体反应. 这种策略似乎是安全和有效的,用于增强无反应患者的疫苗免疫力.

科学领域:

免疫学免疫学免疫学
移植医学移植医学
疫苗学疫苗学疫苗学

背景情况:

肝移植 (LT) 接受者往往对SARS-CoV-2疫苗的反应不佳.
作为一种免疫抑制剂的mycophenolate (MMF) 可以进一步降低这些患者的疫苗免疫性.

研究的目的:

评估MMF的暂时中断是否可以增强对BNT16b2抗SARS-CoV-2疫苗第四剂量的免疫反应.

主要方法:

在接种了三剂疫苗后没有可检测的抗体的LT接受者被纳入.
在第四剂疫苗接种前和后两周内暂停了mycophenolate (MMF).
在接种疫苗后测量了幽默性 (抗SARS-CoV-2 s-RBD抗体) 和细胞 (T细胞) 反应.

主要成果:

所有五位参与者在接种疫苗后都产生了可检测的抗SARS-CoV-2s-RBD抗体,其水平持续.
在三名患者中观察到积极的T细胞反应.
两名患者经历了轻微的,自我限制的SARS-CoV-2感染.

结论:

在第四次mRNA SARS-CoV-2疫苗剂量之前暂停MMF是可行的和安全的.
这种方法可以恢复疫苗诱导的免疫性,在相当一部分不响应的LT接受者.

关键词:

这是一种SARS-CoV-2感染.对抗SARS-CoV-2病毒的疫苗.肝移植肝移植肝移植基酸莫菲蒂尔是什么

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