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在COVID-19疫苗接种和感染后的SARS-CoV-2抗体动力学:现实世界的横截面分析

Ritthideach Yorsaeng¹, Kamolthip Atsawawaranunt², Nungruthai Suntronwong¹

¹Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Pathum Wan, Bangkok 10330, Thailand.

|July 29, 2023

概括

在接种两剂疫苗后,对SARS-CoV-2的抗体水平会下降. 对于未接种疫苗的个人来说,建议进行第三剂,以恢复免疫力并对抗COVID-19的激增.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
公共卫生公共卫生

背景情况:

尽管泰国疫苗接种率很高,但COVID-19大流行仍在持续.
在2022年Omicron激增期间,超过70%的泰国人口被感染.
了解抗体动态对于管理SARS-CoV-2至关重要.

研究的目的:

在接种疫苗和/或感染 (混合免疫) 后分析SARS-CoV-2抗体水平.
为了评估特定于SARS-CoV-2受体结合域 (RBD) 的免疫球蛋白反应.

主要方法:

来自泰国的4126个血清样本的截面分析 (2021年1月至2022年12月).
针对SARS-CoV-2 RBD特有的免疫球蛋白同型 (IgG,IgM,IgA) 的量化.
两剂疫苗接种后抗体水平的评估与混合免疫的评估.

主要成果:

仅仅两剂疫苗接种就导致了较低,迅速下降的抗RBD抗体水平.
混合免疫可能提供更强大和持续的抗体反应 (隐含).
在两剂疫苗接种组中,抗体水平随着时间的推移显著下降.

结论:

对于只有两剂疫苗接种的人来说,建议进行第三剂疫苗,以提升衰弱的免疫力.
补充疫苗接种对于维持对SARS-CoV-2的充分保护至关重要.
进一步研究长期抗体持久性和混合免疫力是有必要的.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.这是一个反RBDD.助推器是一个助推器.幽默免疫力幽默免疫力感染的感染感染.疫苗疫苗疫苗疫苗

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