补充免疫改善了老年人对初级SARS-CoV-2免疫接种无反应的B细胞记忆反应
Marije K Verheul1, Kim H Nijhof1, Mary-Lène de Zeeuw-Brouwer1
1Centre for Immunology of Infectious Diseases and Vaccines, Center for Infectious Disease Control, National Institute for Public Health and the Environment, 3721 MA Bilthoven, The Netherlands.
Vaccines
|July 29, 2023
概括
补充疫苗显著增强了SARS-CoV-2记忆B细胞反应,特别是在可能有低于最佳的初级反应的老年人中. 这确保了强大的免疫防御,以防未来的COVID-19感染.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 对SARS-CoV-2的长期免疫记忆对于COVID-19保护至关重要.
- 记忆B细胞对于在再次接触抗原时快速产生抗体至关重要.
研究的目的:
- 在初级和辅助免疫接种后调查SARS-CoV-2记忆B细胞诱导.
- 专注于老年人免疫反应,这群人群往往容易受到疫苗疗效降低的影响.
主要方法:
- 使用ex vivo ELISpot试验分析记忆B细胞反应 (S1和RBD特异性).
- 包括接受mRNA-1273或BNT162b2疫苗的20至99岁的参与者.
- 对抗体水平,激活度和中和能力与记忆B细胞反应在子集中的比较.
主要成果:
- 大多数参与者在初级免疫接种后开发了特定的记忆B细胞.
- 一个子组,主要是老年人,在初级系列后表现出特定记忆B细胞的低频率.
- 补充疫苗接种显著增加了S1和RBD特异性B细胞记忆频率,即使是在对初级系列没有反应的人中.
结论:
- 补充免疫对于产生对SARS-CoV-2的全面记忆B细胞反应至关重要.
- 在初级SARS-CoV-2疫苗接种后,老年人可能会表现出低于最佳的B细胞记忆反应,这凸显了增强剂的重要性.
- 诱导记忆B细胞预计将在打击未来的SARS-CoV-2再暴露方面发挥重要作用.
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