COVID-19感染,疫苗接种和抗体水平:通过队列研究调查相关性
Gözde Akkuş Kayalı1, Seyfi Durmaz2, İrem Nur Şahin1
1Department of Medical Microbiology, Faculty of Medicine, Ege University, Izmir 35100, Turkey.
Vaccines
|July 29, 2023
概括
感染COVID-19或接种疫苗提供至少六个月的抗体保护. 以前感染过的人可能不需要立即接种疫苗,直到他们的抗体水平下降.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 了解COVID-19感染和接种疫苗后抗体的持续时间和水平对于公共卫生战略至关重要.
- 在不同的场景中评估抗体反应,包括单独感染,接种疫苗后感染和单独接种疫苗,提供了宝贵的见解.
研究的目的:
- 调查COVID-19感染或接种疫苗与抗核体 (anti-N) 和抗尖峰 (anti-S) 抗体水平之间的相关性.
- 为了在感染/接种疫苗后六个月的不同卫生保健工作者群体中比较抗体水平.
主要方法:
- 一项涉及162名医疗保健工作者的队列研究,分为三个组:COVID-19诊断 (未接种疫苗),COVID-19诊断然后接种疫苗 (CoronaVac) 和仅接种疫苗 (CoronaVac).
- 在六个月的随访期间,分析了血清样本的抗N和抗S抗体水平.
- 进行了统计分析,以比较不同组之间的抗体水平.
主要成果:
- 所有参与者在六个月内都具有可检测的抗S抗体.
- 与其他人相比,在COVID-19诊断和接种疫苗的组中观察到显著更高的抗S水平 (p < 0.001).
- 在85.1%的受试者中存在抗N抗体,所有接种疫苗和先前感染的群体均呈阳性.
结论:
- 无论是COVID-19感染还是接种疫苗,都会在至少六个月内赋予保护性抗体水平.
- 以前感染COVID-19的人可能会推迟接种疫苗,直到抗体水平自然下降.
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