在伊朗多次输血患者中对人类血液病毒的表征
Marijn Thijssen1, Gholamreza Khamisipour2, Mohammad Maleki3
1Laboratory for Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
Viruses
|July 29, 2023
概括
这项研究揭示了伊朗患者经常接受输血和健康捐赠者的血液中的多种病毒. 转基因组测序确定了常见的病毒家族和潜在的病原体,突出了输血安全问题.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 基因组学就是基因组学.
背景情况:
- 输血安全对于公共健康至关重要.
- 目前的查方法可能无法检测出所有病原体.
- 人类血液病毒组越来越被认可.
研究的目的:
- 在依赖输血的患者和健康的捐赠者中描述血液病毒组.
- 为了比较患者和捐赠者群体之间的病毒群体.
- 评估与输血相关的潜在风险.
主要方法:
- 使用了Illumina的元基因组测序.
- 分析了来自β-thalassemia患者,血液透析患者和健康捐赠者的血液样本.
- 样品被组合在一起 (每组5个) 用于分析.
主要成果:
- 类病毒和类病毒是最常见的病毒家族.
- 健康捐献者的血液中含有潜在致病病毒的痕迹.
- 血液透析患者显示Anelloviridae的丰富性和丰富性更高.
- 佩吉病毒 (Flaviviridae) 仅在患者中发现.
- 在患者组中观察到真核细胞读数增加.
结论:
- 该研究在伊朗多次输血患者和健康捐赠者中确定了多样化的血液病毒组.
- 研究结果表明,通过输血可能会暴露.
- 需要进一步的研究,以了解这些病毒发现的临床影响.
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