用于非住院成年患者的口服试剂COVID-19 症状轻度至中度
David E Martin1, Neelam Pandey2, Purvi Chavda3
1TrippBio, Inc., Jacksonville, FL 32256, USA.
Viruses
|July 29, 2023
概括
在轻度至中度的COVID-19患者中,Pobenecid显著降低了病毒清除时间,并改善了症状的解决. 这种抗病毒药物表现出剂量依赖的效果,增强恢复,并显示出有利的安全性.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 普罗贝尼西德 (Probenecid) 是一种成熟的痛风药物,具有广泛的抗病毒特性.
- 新出现的证据表明,probenecid对导致COVID-19的病毒SARS-CoV-2的潜在疗效.
- 了解probenecid在管理轻度至中度COVID-19中的作用需要临床调查.
研究的目的:
- 评估probenecid在减少COVID-19患者的病毒载量和症状方面的疗效.
- 确定用于治疗轻度至中度COVID-19的普罗贝尼西德的最佳剂量.
- 为了评估probenecid在这个患者群体中的安全性和耐受性.
主要方法:
- 一个2期,随机,安慰剂控制,单盲,剂量范围研究.
- 75名患有症状,轻度至中度COVID-19的非住院患者每隔12小时接受了probenecid (500mg或1000mg) 或安慰剂,持续5天.
- 主要终点包括到5日病毒清除和症状缓解的时间;次要终点包括到28日病毒载量,住院和死亡.
主要成果:
- 与安慰剂 (11天) 相比,普罗贝尼西德显著减少了与剂量相关的方式 (1000mg: 7天,500mg: 9天) 病毒清除的中位时间.
- 在接受probenecid的患者中,显著增加的比例在第10天报告了完全的症状消失 (1000mg:68%,500mg:56%) 与安慰剂 (20%) 相比.
- 没有报告住院或死亡;不良事件是轻微的,不常见的 (12%),并且在所有组中都是相似的.
结论:
- 乙酸治疗导致SARS-CoV-2病毒清除时间的显著,剂量依赖的减少.
- 普罗贝尼西德的使用导致COVID-19患者的完全症状消失率显著上升.
- 普罗贝尼西德显示出良好的安全性,支持其作为轻度至中度COVID-19的抗病毒疗法的潜力.
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