血蛋白转化酶亚素/素9型 (PCSK9) 作为严重COVID-19的可能生物标志物
Patricia Mester1, Pablo Amend1, Stephan Schmid1
1Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology and Infectious Diseases, University Hospital Regensburg, 93053 Regensburg, Germany.
Viruses
|July 29, 2023
概括
蛋白转化酶亚提利辛/素9型 (PCSK9) 在败血症和COVID-19败血症患者中升高. 较高的PCSK9可能表明COVID-19,但需要在更大的研究中进一步验证.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 蛋白转化酶亚素/素9型 (PCSK9) 影响低密度脂蛋白 (LDL) 的代谢和炎症.
- PCSK9在诸如败血症等炎症状况中的作用是正在进行的研究领域.
研究的目的:
- 调查系统性炎症反应综合征 (SIRS) 或败血症患者的血PCSK9水平,特别是比较COVID-19和非COVID-19病例.
- 探索PCSK9水平与炎症标志物,临床严重程度和败血症患者感染类型之间的相关性.
主要方法:
- 在156名SIRS/败血症患者和68名健康对照人群中测量了血PCSK9水平.
- 患者根据COVID-19状态进行了分层,并分析了与C反应蛋白,白细胞计数,公素和临床因素的相关性.
主要成果:
- 与对照组相比,SIRS/败血症患者,特别是COVID-19患者,表现出较高的血PCSK9水平.
- 血PCSK9与常见的炎症标志物或临床严重性指标 (如通风或透析) 不相关.
- 在非COVID-19组中,根据感染类型 (格拉姆阳性,格拉姆阴性) 观察到PCSK9水平没有显著差异.
结论:
- 血PCSK9水平升高与SIRS/败血症有关,特别是在COVID-19患者中.
- PCSK9显示出作为毒症中COVID-19生物标志物的潜力,需要在更大的队列中进一步调查.
- 在这个患者队列中,PCSK9水平似乎独立于传统的炎症标志物和临床干预措施.
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