血清学确定LIPyV是一种猫类病毒,而不是人类多重瘤病毒
Sergio Kamminga1, Els van der Meijden1, Patricia Pesavento2
1Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Viruses
|July 29, 2023
概括
里昂-IARC多瘤病毒 (LIPyV) 很可能是猫类病毒,而不是人类病毒. 猫的高抗体水平,但不是狗或人类,表明这种新型聚瘤病毒的猫来源.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 比较免疫学比较免疫学
背景情况:
- 已确认的人类多种病毒 (HPyV) 的数量有所增加,其中一些在免疫功能低下的个体中引起疾病.
- 里昂-IARC多瘤病毒 (LIPyV) 在2017年被确定,但很少在人类中检测到,尽管在猫便中发现.
- 人类的低血清发病率表明LIPyV可能不是人类多瘤病毒.
研究的目的:
- 为了调查里昂-IARC多发性瘤病毒 (LIPyV) 是不是猫类而不是人类多发性瘤病毒.
- 为了比较不同动物物种对LIPyV的血清反应.
主要方法:
- 测量了针对LIPyV VP1主要囊蛋白的血清IgG反应.
- 使用内部免疫测试来测试猫 (n=40),狗 (n=38) 和人类 (n=87).
- 在不同物种之间比较了抗体标位.
主要成果:
- 猫对LIPyV.病毒具有非常高的阳性 (92.5%).
- 狗 (31.6%) 和人类 (2.3%) 的血清阳性显著降低.
- 猫对LIPyV的抗体度中位数比狗和人类高100-10,000倍.
结论:
- 高患病率和抗体标位强烈表明LIPyV是一种猫类多种病毒.
- 需要进一步的研究来确定LIPyV感染是否会导致猫的症状.
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