在COVID-19患者中SARS-CoV-2RNAemia和疾病严重程度 患者
Merlin Jayalal Lawrence Panchali1, Choon-Mee Kim2, Jun-Won Seo2
1Department of Internal Medicine, Chosun University College of Medicine, Gwangju 61452, Republic of Korea.
Viruses
|July 29, 2023
概括
血液中的SARS-CoV-2RNAemia (RNAemia) 是COVID-19严重程度和死亡率的重要预测因素. 早期检测RNAemia可以帮助识别高风险患者并指导临床管理策略.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 在COVID-19患者中SARS-CoV-2RNAemia的预后影响尚未完全理解.
- SARS-CoV-2 RNAemia 的临床相关性需要进一步的文档.
研究的目的:
- 为了调查COVID-19患者中SARS-CoV-2RNAemia的临床意义.
- 探索RNAemia与临床特征,疾病严重程度和死亡率之间的关联.
主要方法:
- 一项涉及95名确诊的COVID-19患者的队列研究.
- 在血液中检测SARS-CoV-2RNA的逆转录聚合酶连锁反应 (RT-PCR).
- 后勤回归和Kaplan-Meier生存分析以确定风险因素和生存率.
主要成果:
- 在危急/致命病例 (66.7%) 中,SARS-CoV-2 RNAemia 最常见,其次是严重 (12.5%) 和轻度/中度 (1.7%) 的病例.
- 在入院时和症状出现后的第一周检测到RNAemia,但在第二周没有检测到.
- 疾病严重程度是RNAemia的独立预测指标 (p < 0.021),RNAemia与死亡率增加有关 (p < 0.001).
结论:
- SARS-CoV-2 RNAemia 作为 COVID-19 中临床严重性的预测风险因素.
- 血液RNAemia是评估疾病严重程度和预测COVID-19患者死亡率的关键标志物.
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