关于在实体器官移植受体中治疗疹病毒感染的现有观点
S Reshwan K Malahe1,2, Jeroen J A van Kampen3, Olivier C Manintveld2,4
1Department of Internal Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Viruses
|July 29, 2023
概括
固体器官移植接受者因免疫抑制而面临人类疹病毒 (HHV) 感染的重大风险. 本综述强调了目前在这些脆弱患者中预防和管理HHV疾病的策略.
科学领域:
- 传染性疾病 传染性疾病
- 移植医学 移植医学
- 免疫学 免疫学 免疫学
背景情况:
- 固体器官移植接受者 (SOTRs) 对人类疹病毒 (HHV) 感染非常敏感.
- 免疫抑制疗法对于移植成功至关重要,增加了与HHV相关的风险.
- 在SOTR中感染HHV可导致严重的发病率和死亡率.
研究的目的:
- 提高对SOTRs中HHV疾病负担的认识.
- 提供当前高高温病毒预防和管理策略的全面概述.
- 确定对SOTRs的HHV护理的挑战和未来方向.
主要方法:
- 对当前预防策略的文献综述.
- 对SOTRs中HHV管理现有指南的分析.
- 讨论临床挑战和研究前景.
主要成果:
- 高血压病毒感染对SOTRs构成重大威胁.
- 有效的预防和管理协议至关重要.
- 目前的策略存在差距,需要进一步研究.
结论:
- 了解和解决HHV疾病负担对于SOTR结果至关重要.
- 需要采取综合的预防和治疗方法.
- 未来的研究应该专注于新的治疗和预防干预措施.
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