在保加利亚流通的犀牛病毒基因型,2018-2021年
Irina Georgieva1, Asya Stoyanova1, Svetla Angelova2
1Department of Virology, National Centre of Infectious and Parasitic Diseases, 1233 Sofia, Bulgaria.
Viruses
|July 29, 2023
概括
这项研究在2018-2021年期间在保加利亚确定了34种犀牛病毒 (RV) 基因型. 甲型和C型犀牛病毒是最常见的,而C型犀牛病毒的患病率在COVID-19后增加.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 犀牛病毒 (RV) 是导致呼吸系统疾病的主要原因,具有重大社会经济影响.
- 关于在保加利亚流通的RV基因型的数据有限,因为RV感染不需要报告.
- 了解RV多样性对于公共卫生战略至关重要.
研究的目的:
- 在2018年至2021年期间调查保加利亚流通的犀牛病毒基因型的多样性.
- 在患有类似流感疾病 (ILI) 和急性呼吸道感染 (ARI) 的患者中分析RV物种和基因型分布.
- 提供第一份关于保加利亚RV基因型的综合报告.
主要方法:
- 对RV分离物的5'未翻译区域 (5'UTR) 和VP4-VP2区域的家族遗传学分析.
- 查了1385个鼻抽样检测RV,其中166个样本呈阳性 (11.99%检测率).
- 63个RV阳性样本的基因定型,周期值<25.
主要成果:
- 成功将63个RV分离物分为34种不同的基因型,跨越了A型 (RV-A),B型 (RV-B) 和C型 (RV-C) 类型的犀牛病毒.
- RV-A和RV-C是主要的物种.
- 观察到患病率的转变:RV-A在COVID-19之前更频繁,而RV-C在COVID-19后占主导地位.
- 在三个单独群体中检测到假定的重组事件.
结论:
- 这项研究提供了在保加利亚流传的RV基因型的第一个详细表征.
- 这些发现突出了RV物种的动态循环,在COVID-19后的RV-C显著增加.
- 这些数据为东欧的VR流行病学提供了宝贵的见解,并为未来的公共卫生干预提供了信息.
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