广泛的重组有助于南非蓝舌病病毒的抗原转移

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¹Agricultural Research Council-Onderstepoort Veterinary Institute, Onderstepoort 0110, South Africa.

|July 29, 2023

概括

南非的蓝舌病病毒 (BTV) 现场菌株显示了基因组段的地理选择,推动了重组. 这种进化似乎排除了疫苗菌株,可能导致抗原转移.

科学领域:

兽医病毒学兽医病毒学
分子进化分子进化
流行病学流行病学

背景情况:

蓝舌病病毒 (BTV) 是一种影响反动物的重大病毒性疾病,在南非特有,频繁爆发各种血清型.
每年用活体减弱疫苗 (LAV) 接种疫苗会影响流通的BTV血清型,导致野生型和疫苗菌株的共流通.
南非BTV野外菌株的分子进化和遗传多样性仍然不太清楚.

研究的目的:

为了研究南非BTV野外菌株的遗传多样性.
评估在现场塑造BTV遗传多样性的进化过程.

主要方法:

从35个BTV野外病毒中对11种血清型 (2011-2017) 的完整基因组进行测序.
对从GenBank获得的305个BTV菌株进行测序病毒的家族遗传学分析,包括LAV和参考菌株.
基因组学分析以检测重组和评估进化模式.

主要成果:

遗传学分析揭示了BTV基因组段的地理选择,独立于血清型.
南非普遍存在特定的基因组分类,指导基因组段重组.
重组事件通常不包括疫苗菌株,并且经常涉及Segment-2,有助于抗原转移.

结论:

地理因素在塑造南非BTV基因组段的选择和重组方面发挥着重要作用.
进化动态表明野生类型和疫苗菌株之间存在复杂的相互作用,这对病毒进化有影响.
了解这些过程对于管理BTV和制定有效的控制策略至关重要.

关键词:

反基因转移的转变蓝舌病病毒的感染情况遗传多样性遗传多样性植物基因组学分析进行重新分类,重新分类.

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