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动脉旋转标签对于减少检在患有移植异位功能障碍的患者中的重要性
Wei Wang1,2, Yuanmeng Yu3,4, Xue Li5
1National Clinical Research Center of Kidney Disease, Jinling Hospital, Nanjing Medical University, Nanjing, China.
Journal of magnetic resonance imaging : JMRI
|July 29, 2023
概括
动脉旋转标签 (ASL) 与血清肌素相结合,可以识别可能不需要侵入性活检的移植患者. 这种非侵入性方法提高了诊断特异性,可能减少并发症.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 放射学 放射学是一门学科.
- 移植医学 移植医学 移植医学
背景情况:
- 基移植功能障碍的管理通常需要活检,这是一种带有出血等风险的程序.
- 动脉旋转标记 (ASL) 是一种用于评估组织 perfusion 的非侵入性成像技术.
研究的目的:
- 评估ASL在区分移植受体与需要活检的移植功能障碍患者与不需要活检的受体方面的有效性.
- 确定ASL是否可以帮助避免不必要的侵入性手术.
主要方法:
- 一项前性研究涉及46名患有代移植功能障碍的患者.
- 所有患者都接受了ASL扫描和脏活检.
- 血清肌素,蛋白尿和ASL输液值在需要 (必需) 和不需要 (不必) 活检引导的管理变更的组之间进行了比较.
主要成果:
- 与不必要组相比,NECESSARY组显示出显著更高的血清肌素和较低的皮质ASL值.
- 皮质ASL的AUC为0.75,具有70.97%的特异性,用于识别可能不需要活检的患者.
- 将血清肌素和ASL结合起来,使特异性增加到90.30%.
结论:
- 在选择移植患者中,ASL和血清肌素的联合使用提供了高的特异性,这些患者可能可以避免全移植活检.
- 这种非侵入性方法有助于在移植后全移植功能障碍的临床决策.
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