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Performing and Processing FNA of Anterior Fat Pad for Amyloid
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在上空消化道中的氨基酸沉积,一个单一的研究所经验
Tieying Hou1, Asma Abu-Salah1, Oscar W Cummings1
1Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Ear, nose, & throat journal
|July 29, 2023
概括
口腔粉症与全身性疾病有关,与局部喉粉症不同. 喉 Amyloidosis 也显示与血液恶性瘤的关联,需要彻底的调查.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 病理学 病理学 病理学
- 血液学 血液学 血液学
背景情况:
- 氨基粉症是一种罕见的疾病,其特点是氨基粉蛋白在各种器官中的沉积.
- 喉,口腔和喉的参与不常见,对其临床表现和全身关联的数据有限.
- 了解粉样粉症在这些头部和部部位的独特特征对于诊断和管理至关重要.
研究的目的:
- 评估临床信息,实验室结果和病理发现,对患有影响喉,口腔和喉的粉症的患者.
- 为了比较喉,口腔和喉 Amyloidosis 的系统性关联.
- 为了识别风险因素,并指导头部和部 Amyloidosis 的诊断工作.
主要方法:
- 在2000年至2020年期间,对28名被诊断患有喉,口腔或喉 Amyloidosis 的患者的39个样本进行了回顾性审查.
- 收集和分析临床表现,放射性发现,实验室结果 (包括蛋白质电泳) 和病理发现.
- 在一个案例中,使用质谱法来确定形状.
主要成果:
- 喉 Amyloidosis (12名患者) 大多是局部的,真正的声带是最常见的位置. 一个病例显示出粉样蛋白转基因素 (ATTR) 类型.
- 口腔氨基粉症 (12名患者) 经常涉及舌头 (75%) 并显示出与全身疾病的相关性显著更高 (89%的测试,包括造血性恶性瘤和轻链氨基粉症) (P < .01).
- 喉 Amyloidosis (7名患者) 显示了50%的关联与活检确认的血液形成性恶性瘤,特别是在口腔和下.
结论:
- 喉 Amyloidosis 通常是一个局部疾病.
- 口腔粉症具有显著的系统性参与风险,需要全面的诊断评估.
- 喉 Amyloidosis,特别是在口喉和下喉,经常与潜在的血液恶性瘤相关,而鼻的参与似乎不那么相关.
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