在甲状腺相关的眼科医症中改变了动态大脑活动和功能连接
Wen-Hao Jiang1, Jun Liu1, Jiang Zhou1
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Human brain mapping
|July 29, 2023
概括
甲状腺相关眼科医症 (TAO) 患者表现出大脑活动动态和功能连接的改变,特别是在视觉和认知领域. 这些变化与视力障碍相关,为TAO提供了洞察力.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
背景情况:
- 甲状腺相关的眼科医症 (TAO) 与大脑功能障碍有关.
- 以前的研究很少关注TAO中大脑活动和功能连接 (FC) 的动态特征.
研究的目的:
- 通过静止状态功能磁共振成像 (rs-fMRI) 来研究TAO患者大脑活动和FC的时间变异性的变化.
- 通过检查动态大脑功能来探索TAO背后的神经生物学机制.
主要方法:
- 在47名TAO患者和30名健康对照 (HCs) 上使用了rs-fMRI.
- 计算低频波动的动态振幅 (dALFF),以评估时间大脑活动的可变性.
- 进行了基于种子的动态功能连接 (dFC) 分析,以评估大脑区域之间的通信变异性.
- 分析了dALFF,dFC和临床指标之间的相关性.
主要成果:
- 在TAO患者中,左上椎 (SOG) 和椎 (CUN) 的dALFF减少.
- 在左下额头回环 (IFGtriang,ORBinf),胰岛 (INS),上回环 (STG) 和极 (TPOsup) 中观察到dALFF的增加.
- 在左STG和右中椎 (MOG) 之间,以及在左TPOsup和右骨裂 (CAL/MOG) 之间发现了减少的dFC.
- 改变SOG/CUN中的dALFF与视觉敏度和生活质量 (QoL) 对视觉功能有积极的相关性.
结论:
- TAO患者在视觉,情绪和认知相关领域的脑活动中表现出异常的时间变化.
- 减少FC的时间变化与TAO的视力缺陷有关.
- 这些发现增强了对TAO神经生物学基础的理解.
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