甲状腺激素药物药物坚持与痴呆症风险的关联
Saemi Han1,2, Seogsong Jeong3, Seulggie Choi4
1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea.
The Journal of clinical endocrinology and metabolism
|July 29, 2023
概括
坚持甲状腺激素药物治疗可能会降低甲状腺功能低下症的老年人痴呆风险. 更好的坚持,特别是对甲状腺激素药物治疗,与患阿尔茨海默病的风险降低有关.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 甲状腺功能低下是痴呆症的一个已知的危险因素.
- 甲状腺激素药物坚持和低甲状腺症患者痴呆风险之间的关系尚不清楚.
研究的目的:
- 调查甲状腺激素药物坚持与新诊断的甲状腺功能低下症的老年人痴呆风险之间的关联.
主要方法:
- 一项以人口为基础的队列研究包括41,554名50岁以上的新发性甲状腺功能低下症的成年人.
- 对参与者进行了痴呆发病率,死亡或直到2020年12月31日的跟踪.
- 考克斯的比例危险回归模型被用来评估基于药物持有率 (MPR) 的痴呆风险.
主要成果:
- 较高的坚持 (第四四分位数MPR) 与较低的坚持群体相比,与整体痴呆症风险降低14%有关.
- 增加守率 (MPR ≥0.8) 显示阿尔茨海默病风险降低,但没有发现血管痴呆症的一致关联.
- 该研究在参与者中发现了2,120例痴呆病例.
结论:
- 更好地遵守甲状腺激素药物治疗可能有助于预防老年人患有甲状腺功能低下症的痴呆症,特别是阿尔茨海默病.
- 甲状腺激素药物治疗的坚持提供了超越症状管理和心血管风险降低的潜在好处,包括减轻痴呆风险.
- 这些发现强调了药物遵守在治疗甲状腺功能低下症及其潜在的长期神经后果的重要性.
关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.甲氧氨酸 (Levothyroxine) 是一种抗氧化剂.氨酸氨酸 (Liothyronine) 是一种氨酸.甲状腺功能障碍 甲状腺功能障碍血管痴呆症是一种精神病.更多相关视频
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