亲属肠道多重症和设备辅助肠镜检查:我们的情况如何?
Giuseppe Losurdo1, Milena Di Leo2, Salvatore Rizzi1
1Section of Gastroenterology, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, Bari, Italy.
设备辅助肠镜 (DAE) 对于在遗传性多重症综合征中清除小肠多重体至关重要. 建议对Peutz-Jeghers综合征 (PJS) 进行查,而DAE主要有利于PJS和家族腺瘤多重症 (FAP) 患者的小肠多重症.
科学领域:
- 胃肠病学和遗传性癌症综合征
背景情况:
- 遗传性多重症综合征会增加结直肠癌的风险.
- 家庭腺瘤多重症 (FAP),皮茨-杰格斯多重症 (PJS),青少年多重症,考登和林奇综合征是其中的重要例子.
- 在这些遗传性疾病中的一些情况下,小肠息肉是令人担忧的.
研究的目的:
- 审查设备辅助肠镜 (DAE) 在遗传性多重症综合征中的小肠多重体管理中的作用.
- 概述风险患者群体中小肠小息肉的当前查和治疗策略.
主要方法:
- 进行了文学叙事审查.
- PubMed数据库在2022年11月进行了搜索.
- 综合了有关诊断和治疗肠镜学的关键发现.
主要成果:
- 查小肠小息肉是特别推PJS,使用MRI或VCE每1-3年.
- DAE对于治疗性多角切除术至关重要,特别是在引起症状或大于几毫米的息肉中.
- 单 (SBE) 和双气球肠镜 (DBE) 都可以切除高达10厘米的息肉,尽管美国指导方针限制了指示.
结论:
- 在特定的遗传性多综合征中,DAE在小肠多的管理中发挥着至关重要的作用.
- 只有患有PJS和FAP的患者,具有显著的小肠多负担,可能会从DAE中受益.
- 目前的指导方针建议针对遗传性多症综合征中小肠多的查和治疗干预措施.
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