检查胎儿皮质厚度,妊娠年龄和母亲心理痛苦之间的关系
Josepheen De Asis-Cruz1, Jung-Hoon Kim1, Dhineshvikram Krishnamurthy1
1Developing Brain Institute, Children's National, Washington, DC, USA.
Developmental cognitive neuroscience
|July 29, 2023
概括
怀孕期间母亲的心理压力可能会影响胎儿的大脑发育,可能会改变特定区域的皮质厚度. 需要进一步的研究来证实这些微妙的子宫内变化.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 医疗成像医学成像
背景情况:
- 产前暴露于母亲的压力,焦虑和抑郁症与皮质厚度 (CT) 的降低有关.
- CT变化与不良的神经精神病学结果有关.
- 了解子宫内大脑发育对于早期干预至关重要.
研究的目的:
- 研究暴露于母亲心理痛苦的胎儿的全球和区域皮层厚度 (G/RCT) 变化.
- 为了确定受产前孕产妇痛苦影响的特定大脑区域.
- 探索胎儿发育过程中皮质变化的出现.
主要方法:
- 分析了来自177名低风险孕妇健康胎儿的265项脑部MRI研究.
- 从皮质灰色物质 (CGM) voxels.测量全球皮质厚度 (GCT).
- 来自82个皮层区域的区域皮层厚度 (RCT) 估计.
主要成果:
- 全球和区域皮质厚度 (GCT和RCT) 与妊娠年龄 (GA) 在87%的地区相关.
- 胎儿暴露在母亲的痛苦中显示出与RCT在近海马区域,腹中前额叶皮质和上边缘回环中最强烈的关联.
- 观察到的胎儿区域大脑变化与新生儿和暴露于产前母亲痛苦的儿童的模式保持一致,但没有经过多次比较校正.
结论:
- 与产前母亲心理困扰相关的皮质变化可能在子宫内出现.
- 这些早期发育变化或研究人口中较低的孕产妇痛苦水平的微妙性可能解释了经过校正后缺乏统计学意义的情况.
- 鼓励以未来的假设驱动的研究,使用更广泛的母亲心理健康得分范围.
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