中性和阴离子 (II) 复合物与替代的甲:特征,抗菌活性,与生物大分子的相互作用
Maria Gkritzali1, Martha Georgila2, Antonios G Hatzidimitriou1
1Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
Journal of inorganic biochemistry
|July 29, 2023
概括
合成和研究了新的 (II) 复合物,其中含有替代的甲. 含有neoc作为辅配体的复合物显示出对测试细菌最强的抗菌活性.
科学领域:
- 协调化学 协调化学
- 生物有机化学 生物有机化学
- 材料科学 材料科学 材料科学
背景情况:
- 由于其多样化的应用, (II) 复合物引起人们的兴趣.
- Salicylaldehyde衍生物和 N,N'-捐赠体连接体是协调化学中常见的构建块.
- 了解金属-连接体相互作用对于开发新的功能性材料至关重要.
研究的目的:
- 合成和表征新型中性和阴离子 ((II) 复合物.
- 研究这些复合物的DNA结合方式和血清白蛋白相互作用.
- 评估合成的 (II) 复合物的抗菌疗效.
主要方法:
- 合成 (II) 复合物与替代的甲和N,N'-捐赠者辅配体.
- 使用各种光谱和晶体学技术进行表征,包括单晶X射线晶体学.
- 使用各种生物物理技术进行DNA相互作用研究.
- 血清白蛋白结合试验. 血清白蛋白结合试验.
- 对选择的细菌菌株进行抗菌活性测试.
主要成果:
- 十个II) 复合物 ([Ni(X-salo) 2(H2O) 2,[Ni(3,5-diCl-salo) 2(neoc/phen) 和[Ni(X-salo) N,N'-donor) 2(PF6)) 已成功合成和表征.
- 晶体结构揭示了盐酸甲的双重协调.
- 中性复合体表现出介质DNA结合,而阴性复合体表现出静电相互作用.
- 所有的复合物都紧密地和可逆地与血清白蛋白结合.
- 含有2,9-二甲基-1,10-氨 (neoc) 的复合物作为辅配体,表现出最高的抗菌功效.
结论:
- 合成的 (II) 复合物表现出多种不同的DNA结合方式和可逆的血清白蛋白相互作用.
- 抗菌活性受到协配体的影响,其中含有neoc的复合物是最有效的.
- 这些发现突显了这些 (II) 复合物作为抗菌剂的潜力.
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