在急性精神分裂症住院患者中,C反应蛋白与炎症比率之间的相关性:它们是否相关?
Vicent Llorca-Bofí1, Miquel Bioque2, Maria Font3
1Department of Medicine, University of Barcelona, Barcelona, Spain; Department of Psychiatry, Santa Maria University Hospital Lleida, Lleida, Spain; Institut de Recerca Biomèdica de Lleida (IRBLleida), Spain.
Journal of psychiatric research
|July 29, 2023
概括
像中性细胞-淋巴细胞比率 (NLR) 这样的炎症比率与精神分裂症患者的C-反应蛋白 (CRP) 有着中度的联系. NLR和多期精神分裂症显示出与CRP水平的最强相关性.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 免疫失调与精神分裂症 (SCZ) 有关.
- 反应蛋白 (CRP) 和炎症比率是潜在的生物标志物.
- 在急性SCZ住院患者中,CRP和特定炎症比率之间的关系需要进一步研究.
研究的目的:
- 在急性SCZ住院患者中研究CRP和炎症比率 (NLR,PLR,MLR,BLR) 之间的关联.
- 分析性别和情节类型如何影响这些关联.
主要方法:
- 这项研究包括698名急性SCZ住院患者.
- 在CRP和NLR,PLR,MLR和BLR之间进行了相关性分析.
- 多重线性回归分析了独立的关联.
- 亚组分析考虑了性别和情节类型 (第一集与多集).
主要成果:
- CRP与NLR (r=0.338),PLR (r=0.271) 和MLR (r=0.148) 显示出显著的相关性,但与BLR没有显著的相关性.
- NLR,MLR和PLR独立地与更高的CRP水平相关.
- 关联在两性之间是一致的.
- 在第一集和多集的SCZ中,NLR和MLR的关联仍然存在,在多集的SCZ中,联系更强.
结论:
- 在急性SCZ中,炎症比率与CRP低至中度相关.
- 中性细胞-淋巴细胞比率 (NLR) 和多期SCZ显示出与CRP的最强相关性.
- 炎症比率可以作为SCZ研究中CRP的补充生物标志物.
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