在一组中国妇女中确定多式模式的衰老时钟
Jiaming Li1, Muzhao Xiong1, Xiang-Hong Fu2
1CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
Med (New York, N.Y.)
|July 29, 2023
概括
研究人员使用113名女性的多式联络数据开发了新的衰老指标和时钟. 这些工具量化了生物年龄,并评估了衰老减速,有助于为老龄人口制定复苏策略.
科学领域:
- 老年学和再生医学的研究.
- 生物标志物发现发现
- 系统生物学 系统生物学
背景情况:
- 将衰老复苏策略转化为临床实践对于日益增长的全球老龄化人口至关重要.
- 精确量化衰老及其逆转是必要的,以解决衰老的复杂性和变化.
- 目前的方法缺乏精确度,无法有效监测和逆转衰老过程.
研究的目的:
- 开发精确的指标来量化生物年龄及其逆转.
- 创建基于多式联运数据的整合性和定制化的老化时钟.
- 为了告知衰老复苏策略的临床发展.
主要方法:
- 分析了来自113名女性的多式数据 (转录,蛋白质,代谢物,微生物,临床值).
- 开发一个整合性的老龄化钟和定制的老龄化钟.
- 识别与衰老相关的特征和模式.
主要成果:
- 他们定义了四种不同的衰老模式:慢性炎症,脂质新陈代谢,激素调节和组织健康.
- 显而易见的生物路径显示了变化浪潮,在生命的第三和第五十年达到顶峰.
- 开发的衰老时钟准确地测量了生物年龄,并通过激素替代疗法评估了衰老减速.
结论:
- 已建立的新型衰老指标捕捉了全身生理学调节障碍.
- 这些指标为监测衰老提供了有价值的框架.
- 这些发现支持临床开发衰老复苏策略.
关键词:
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