对鼻腔的声学药物输送方面的进展:综合性审查
Oveis Pourmehran1, Kavan Zarei2, Jeremie Pourchez3
1Department of Surgery-Otolaryngology Head and Neck Surgery, Adelaide Medical School, The University of Adelaide, Adelaide 5011, Australia; Department of Surgery-Otolaryngology Head and Neck Surgery, Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, Woodville, South Australia, Australia.
International journal of pharmaceutics
|July 29, 2023
概括
声学药物输送 (ADD) 通过优化气溶颗粒和声波来提高鼻炎治疗效果,以更好地管理慢性鼻炎 (CRS). 这种有针对性的方法改善了鼻中药物的沉积,为传统方法提供了更有效的替代方案.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生物医学工程 生物医学工程
- 制药科学 制药科学
背景情况:
- 慢性鼻炎 (CRS) 显著影响患者的生活质量,并导致大量的医疗保健费用.
- 目前的药物输送方法,如鼻喷雾和灌,对CRS的治疗效果有限.
- 声学药物输送 (ADD) 是一种新的,有针对性的方法,可以将药物直接输送到鼻腔.
研究的目的:
- 审查影响Acoustic Drug Delivery (ADD) 对鼻腔药物输送效率的因素.
- 探索ADD在改善慢性鼻炎 (CRS) 治疗方面的潜力.
主要方法:
- 检查气溶颗粒的特性 (大小,密度) 以及它们对ADD的影响.
- 分析空气声学参数,包括振荡幅度和声波引入.
- 研究入口流条件及其对鼻腔和鼻系统中药物沉积的影响.
主要成果:
- 更小的气溶颗粒大小提高了ADD的效率,而更大的尺寸或增加的密度阻碍了它.
- 空气塞在 sinus ostium 的振荡幅度是ADD有效性的关键因素.
- 使用与鼻腔-鼻腔系统共振频率调整的声波,可显著改善气溶沉积.
结论:
- 声学药物输送 (ADD) 显示出对CRS和其他鼻疾病的更有效和更有针对性的治疗有希望.
- 优化粒子特性和声学参数是最大化ADD效率的关键.
- 未来的研究应该专注于先进的建模,患者特异性解剖学,新浪波形和长期临床评估.
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