使用卡里昂装置进行皮肤部除术:结果在相称和不相称的功能性部吐中
Piotr Kałmucki1, Janusz Lipiecki2, Klaus K Witte3
1Poznan University of Medical Sciences, HCP Medical Center, Poznan, Poland.
American heart journal
|July 29, 2023
概括
使用卡里昂装置进行间接的结婚整形术有效地降低了心力衰竭患者的功能性额叶回 (FMR) 减少排泄率 (HFrEF) 患者. 相对的FMR患者在治疗后也经历了显著的左心室逆向重塑.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 心脏衰竭管理的管理
背景情况:
- 通过皮肤进行边缘到边缘修复 (TEER) 结果的差异对于功能性额头回 (FMR) 在心力衰竭中减少排气分数 (HFrEF) 可能源于患者人群的差异.
- 与不成比例的FMR患者相比,患有比例的FMR的患者可能对TEER的反应不那么有利.
- 这种比例与不相称的FMR分类对其他皮肤干预措施的适用性仍然不清楚.
研究的目的:
- 为了比较HFrEF患者的临床和心声学结局,这些患者有相称和不相称的FMR,使用卡里隆装置间接取消造形.
- 在不同FMR亚组中调查皮肤穿 mitra annuloplasty 的有效性.
主要方法:
- 三项临床试验的综合分析,涉及患有FMR的患者.
- 患者选择标准包括持续性FMR (2+至4+级),减少喷射分数和左心室末端透气直径 (LVEDD) >5.5厘米.
- 患者被分为比例的FMR (有效吐孔面积/LV终端透析体积 [EROA/LVEDV] 比率<0.15) 和不成比例的FMR (EROA/LVEDV比率>0.15) 组.
主要成果:
- 在12个月后,相称和不相称的FMR组都显示了额头上变量 (MR) 的显著改善,包括回体积,EROA和静脉收缩.
- 患有比例性FMR的患者显示左心室 (LV) 体积和直径的临床相关和统计学显著改善.
- 在比例度 (作为连续变量) 与对卡里昂疗法的重塑反应之间没有发现独立的相关性.
结论:
- 使用卡里昂装置进行皮肤部解剖手术,有效地减少了比例和不相称的FMR患者的MR.
- 卡里昂装置还可以促进在患有比例性FMR的患者中进行LV逆重塑.
- 需要进一步的大规模试验来验证对改造的长期影响.
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