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Updated: Jul 20, 2025

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一种多层次的等级贝叶斯式方法来推导二氧化类化合物的有毒等价因子

Caroline Ring1, Alexander Blanchette2, William D Klaren2

  • 1ToxStrategies, Austin, TX, USA.

Regulatory toxicology and pharmacology : RTP
|July 29, 2023
PubMed
概括

世界卫生组织 (WHO) 开发了一种新的计算工作流程,以改善二氧化类化合物的毒性等效因子 (TEF). 这种方法为数据差的同源提供了更好的不确定性表征.

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Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
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