在美洲的内心肌纤维化协作研究:EMF-SIAC注册表
Cristhian E Scatularo1, Edith Liliana Posada Martínez2, Ana C Alba3
1Department of cardiology, Sanatorio de la Trinidad de Palermo, Buenos Aires, Argentina.
Current problems in cardiology
|July 29, 2023
概括
内心肌纤维化 (EMF) 通常表现为心力衰竭 (HF) 和心房动 (AF). 诊断往往发生迟,HF管理和手术是这种限制性心肌病的关键治疗方法.
科学领域:
- 心脏病学 心脏病学
- 内部医学 内部医学
- 病理学 病理学 病理学
背景情况:
- 内心肌纤维化 (EMF) 是一种限制性心肌病,其特征是下内心肌纤维化和eosinophilic透.
- 电磁场通常表现为心力衰竭 (HF) 或心房动 (AF).
- 免疫抑制在EMF早期阶段是有效的,但在慢性阶段是不有效的.
研究的目的:
- 在整个美洲,对心脏内膜纤维化 (EMF) 患者进行表征.
- 分析EMF的临床,生化和成像特征.
- 了解EMF的诊断和治疗方法.
主要方法:
- 追溯的,多中心的,横截面的注册表研究.
- 纳入标准:通过成像诊断的EMF患者≥18岁 (Mocumbi标准).
- 临床,生化和成像变量的分析;在某些情况下,内心肌组织活检.
主要成果:
- 包括54名患者:52%为男性,平均年龄为47岁,87%为异常病因.
- 高频率的HF (76%),AF (35%) 和缺血性中风 (15%).
- 排泄分数≥50%在65%;严重的额头骨吐在21%;严重的三骨吐在33%.
结论:
- 电磁场患者表现出高频率的HF,AF和栓塞事件.
- 诊断往往是延迟的,晚期需要HF管理和手术干预.
- 成像方法对于EMF诊断至关重要,在一小部分患者中,活检证实了这一点.
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