来自Sanguisorba officinalis根的triterpenoids及其Nrf2刺激活动
Longlong Wu1, Jingwen Liu2, Kaixian Chen1
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China.
Phytochemistry
|July 29, 2023
概括
在Sanguisorba officinalis根中发现了13种新的ursane类型的三类植物. 几种化合物表现出显著的Nrf2激活,突出了它们作为天然抗氧化剂的潜力.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 红花科 (Sanguisorba officinalis) 是一种具有传统使用历史的药用植物.
- 三聚类是一种多样化的自然化合物,具有各种生物活动.
- 核因子红色素2相关因子2 (Nrf2) 途径对于细胞防御氧化应激至关重要.
研究的目的:
- 从Sanguisorba officinalis根源中分离和表征新的乌尔桑类型的三类.
- 评估孤立化合物的Nrf2激活潜力.
- 为了研究这些三类化合物关于Nrf2激活的结构-活性关系.
主要方法:
- 使用染色学技术分离和净化三烯酸.
- 通过光谱方法 (NMR,MS) 和X射线晶体学阐明结构.
- 在293个T细胞中的体外Nrf2激活测定和细胞毒性评估.
主要成果:
- 确定了13种新的ursane类型的三类化合物 (sangosides A-M),以及36种已知的化合物.
- 一些孤立的化合物,包括新的和已知的三类化合物,表现出显著的Nrf2激动作用.
- 结构-活性关系分析表明,特定的结构特征,如双键和碳基/基,与Nrf2激活相关.
结论:
- 桑格索巴 (Sanguisorba officinalis) 是一个丰富的生物活性乌尔桑类型三类的来源.
- 已识别的化合物,特别是具有特定结构动机的化合物,显示出作为Nrf2激活剂的前景.
- 这些发现支持对S. officinalis进行进一步的研究,以开发针对Nrf2通路的天然抗氧化剂和治疗剂.
关键词:
抗氧化剂是一种抗氧化剂.Nrf2激活活动活动罗莎属植物 (Rosaceae) 是一个植物.血 (Sanguisorba officinalis) 是一个有血的植物.这种类型的Triterpenoids.更多相关视频
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