这是大脑活动的自主模式
Ehsan Shokri-Kojori1, Dardo Tomasi1, Sukru B Demiral1
1National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Progress in neurobiology
|July 29, 2023
概括
睡眠不足 (SD) 改变了大脑活动,增加了自主网络中的同步低频振荡. 在SD期间,这种自主性脑活动模式与明显的自主-中枢神经系统相互作用和较低的粉样β负担相关.
科学领域:
- 神经科学是一个神经科学.
- 自主神经系统的自主神经系统
- 睡眠研究 睡眠研究
背景情况:
- 自主和中枢神经系统之间的相互作用对大脑功能至关重要,但它在睡眠不足 (SD) 等生理挑战中的作用仍然不太清楚.
- 了解这些相互作用对于维持大脑健康和在压力下功能至关重要.
研究的目的:
- 研究睡眠不足对自主-中枢神经系统相互作用和大脑活动的影响.
- 探索在睡眠剥夺期间自主相关的大脑网络,生理信号和大脑粉样β负担之间的关系.
主要方法:
- 使用功能磁共振成像 (fMRI) 来测量大脑活动和心肺呼吸信号.
- 采用正子发射断层扫描 (PET) 来评估基线大脑粉样蛋白β负担.
- 分析了自主和中枢神经系统网络之间的低频 (<0.1 Hz) 同步活动和相连贯性.
主要成果:
- 睡眠不足显著增加了自主网络 (AN) 中的同步低频活动,包括注意力,视觉和感觉运动区域.
- SD诱导了脉冲信号和中枢大脑网络,呼吸系统变异和小脑网络之间的显著相一致性.
- 在SD期间更高的AN低频功率与脉冲-介质和呼吸-小脑网络连贯性相关 (R2 = 0.78).
- 在SD期间增加的AN低频功率与大脑下部的粉样β负担有关.
结论:
- 缺乏睡眠会诱导一种独特的自主模式的同步大脑活动,其特点是特定的自主-中枢神经系统相互作用.
- 睡眠剥夺期间的全球皮质同步与大脑清除机制直接相关,正如与粉样蛋白β负担的关联表明的那样.
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