血性干细胞移植幸存者血性恶性病患者的药物坚持:一种定性研究
Hermioni L Amonoo1, Emma C Deary2, Annie Wang3
1Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Transplantation and cellular therapy
|July 29, 2023
概括
干细胞移植患者的药物坚持是具有挑战性的,因为外部因素如药房问题和内部因素如家庭职责等. 支持系统和组织工具显著提高了这些患者的坚持.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 患者坚持的研究研究.
背景情况:
- 药物坚持对于患有血液性恶性瘤的患者来说至关重要,这些患者在异构造血型干细胞移植 (HSCT) 后的血液性恶性瘤.
- 这种患者群体经常经历药物不服药的挑战.
- 缺乏对影响HSCT接受者的坚持因素的全面了解.
研究的目的:
- 探索复杂的患者和药物相关因素,影响HSCT接受者的药物坚持.
- 在这个特定的患者群体中识别药物坚持的促进者和障碍.
主要方法:
- 进行了30次深入的,半结构化的定性访谈,在异构HSCT后的180天内与患者进行了采访.
- 探索了影响坚持的身体,社会,心理和社会人口因素.
- 使用NVivo软件进行采访数据的转录和编码.
主要成果:
- 确定了外部障碍:管理多家药房,保险问题和剂量时间.
- 确定了内部障碍:家庭责任.
- 促进者包括照顾者/临床医生的支持,先前的治疗方案经验和药丸组织工具.
结论:
- 药物坚持障碍是多方面的,包括身体,心理,组织和社会领域.
- 虽然副作用和药物负担并没有直接降低坚持,但它们增加了心理痛苦.
- 干预措施应解决药物副作用,心理健康和社会支持,以改善药物遵守.
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