对蛋白质组学,表观遗传学和代谢学数据的综合分析揭示了最近与慢性创伤后应激障碍的途径激活模式的分歧
Seid Muhie1, Aarti Gautam2, Burook Misganaw3
1Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA; The Geneva Foundation, Silver Spring, MD 20910, USA.
Brain, behavior, and immunity
|July 29, 2023
概括
多omics分析揭示了近期与慢性创伤后应激障碍 (PTSD) 中不同的分子特征. 早期的PTSD显示出恒温路径的激活,而慢性PTSD则表明炎症和神经退行.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 创伤后应激障碍 (PTSD) 是一种复杂的心理健康状况,具有不同的过程.
- 了解PTSD进展的分子基础对于开发向疗法至关重要.
研究的目的:
- 通过使用多omics数据,研究近期发病和慢性创伤后应激障碍 (PTSD) 的分子基础.
- 识别与PTSD严重程度和进展相关的独特分子特征.
主要方法:
- 在两个独立队伍的血液样本上进行了协同的代谢学,蛋白学和DNA甲基组分析.
- 分析了来自159名近期PTSD (<1.5年) 的现役参与者和300名患有慢性PTSD (>7年) 的退伍军人的多项数据集.
主要成果:
- 最近的PTSD (现役) 显示了与恒温过程,细胞重塑,神经发生和寿命相关的激活分子签名.
- 慢性PTSD (退伍军人) 显示了与炎症,神经退行,心血管/代谢障碍和细胞衰竭相关的改变标志.
- 不同的途径激活表明在早期和晚期PTSD阶段之间存在明显的分子变化.
结论:
- 早期的PTSD可能涉及重新校准或补偿的分子反应,以减轻病理.
- 慢性PTSD与多系统分子失调有关,包括炎症和神经退行.
- 多omics分析提供了关于PTSD随时间的分离分子轨迹的见解.
关键词:
现役士兵 现役士兵 现役士兵 现役士兵 现役士兵慢性创伤后应激障碍 (PTSD) 是一种疾病.伴随性疾病 伴随性疾病恒常状态 (Homeostasis) 是一种恒常状态.多个omics的多个omics.最近出现的PTSD.退伍军人退伍军人退伍军人创伤后应激障碍 (PTSD) 是一种创伤后应激障碍.更多相关视频
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