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干预性死性肠球炎研究的结果报告:系统性审查.
Otis C van Varsseveld1, Daphne H Klerk2, Ingo Jester3
1Department of Surgery, Division of Pediatric Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Journal of pediatric surgery
|July 29, 2023
概括
结核性肠球炎 (NEC) 研究显示,结果报告各异,很少有人专注于患者生命的影响. 制定一个标准化的NEC核心结果集对于一致和相关的研究来改善婴儿结果至关重要.
科学领域:
- 新生儿研究新生儿研究
- 临床试验方法论 临床试验方法论
- 儿科外科手术 儿科外科手术
背景情况:
- 死亡性肠球炎 (NEC) 的发病率不断增加,需要改进治疗策略.
- 目前的NEC治疗研究受到不一致的结果报告和有限的疗效研究的阻碍.
- 需要对干预性NEC研究中的结果报告进行分析.
研究的目的:
- 系统地审查和分析最近对死性肠球炎 (NEC) 的干预研究报告的结果.
- 识别NEC治疗研究中的结果测量的异质性和差距.
主要方法:
- 2016年1月至2023年6月期间发表的干预性NEC研究的系统审查.
- 包括临床试验和对NEC患者的实践变化队列研究 (贝尔阶段≥IIa).
- 排除诊断/预防研究和非英语出版物;结果分类和描述性分析.
主要成果:
- 包括15项研究,报告了6个独特结果的中位数 (范围1-19).
- 确定了66个独特的结局,其中64%仅在一项研究中报告.
- 死亡率是最常见的结果 (73%),而"生命影响"的结果是最不常见的 (20%的研究).
结论:
- 在干预性NEC研究的结果报告中存在显著的异质性.
- 目前的NEC研究中显著缺乏与"生命影响"相关的结果.
- 建议建立一个NEC核心结果集,以提高一致性和患者相关性.
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