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那不勒斯预后分数在食道癌症:预后和超越
Metin Demir1, Nazım Can Demircan1
1Erzurum Regional Training and Research Hospital, Department of Medical Oncology, 25100 Erzurum, Turkey.
Bulletin du cancer
|July 29, 2023
概括
那不勒斯预后得分 (NPS) 可以预测接受化疗放射治疗 (CRT) 的食道癌 (EC) 患者的结果. 高NPS表明复发风险更高,这表明手术可能有利于特定的患者群体.
科学领域:
- 在瘤学瘤学.
- 炎症和癌症生物学
背景情况:
- 炎症在瘤进展中起着至关重要的作用.
- 那不勒斯预后得分 (NPS) 是一种新兴的基于炎症的标记.
- 以前的研究表明,NPS在经过手术治疗的食道癌 (EC) 患者中具有实用性.
研究的目的:
- 评估EC患者中NPS的预后和预测价值,这些患者接受了前期化疗放射治疗 (CRT).
主要方法:
- 分析了成年EC患者 (状细胞癌或腺癌).
- 使用日志等级测试来比较生存结果.
- 考克斯回归分析确定了总生存时间 (OS) 的独立预后因素.
主要成果:
- 那不勒斯预后得分 (NPS) 在那不勒斯预后组 (NPG) 的中位数整体存活率 (OS) 中显示出显著的差异 (P=0.007).
- 在CRT后的手术改善了NPG 1和NPG 2患者的生存率 (分别P<0.001和P=0.009).
- 多变量分析证实NPS是OS的独立预后标志物 (HR=1.28,P=0.02).
结论:
- 对于接受前期CRT的EC患者来说,NPS可以作为一个有价值的预后标志物.
- 升高的NPS与瘤复发的风险增加有关.
- 在NPG 1和2患者的诊断时考虑进行外科手术可能会改善结果.
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