对患有多器官的儿科患者的发病诊断
Mingkun Wu1, Haijuan Xiao2, Yan Xiao1,3
1National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, No.9 Dong Dan San Tiao, Dongcheng District, 100730, Beijing, P. R. China.
Diagnostic pathology
|July 29, 2023
概括
一名儿科患者从由血液感染引起的脏和肝脏腹中恢复过来. 甲基因组学确定了多微生物细菌病和人类腺病毒C (HAdV-C) 作为导致因素.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 病毒学 病毒学
背景情况:
- 在健康的儿童中,多器官是罕见的.
- 血流感染可能导致扩散形成.
研究的目的:
- 在儿科患者中识别脏和肝脏的致病原体.
- 调查多微生物细菌病和病毒感染在发育中的作用.
主要方法:
- 对患有脏和肝脏的儿科病例的临床分析.
- 采样采集:脏活检,抽样,血.
- 病原体鉴定:基因组学下一代测序 (mNGS),传统方法,病毒隔离,抗体定位.
主要成果:
- 包括无氧细菌 (例如, Bacteroides fragilis) 在内的多微生物细菌病被确定为形成的主要贡献者.
- 检测到全身人类腺病毒C (HAdV-C) 感染,并成功隔离了病毒.
- 在症状发作后观察到HAdV-2中和抗体的低位数 (1/4).
结论:
- 这一案例突出了健康儿童中多器官的罕见发生情况.
- 这些发现表明,多微生物无氧细菌病和人类腺病毒C感染在病原发生过程中起着协同作用.
- 需要进一步的研究来阐明将HAdV-C感染与形成联系在一起的确切机制.
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