根据系统药理学,Sagacious孔子的枕头精液的活性成分和分子机制用于治疗认知障碍
Zhitao Hou1,2,3,4,5, Xinyu Yang2,6, Ling Jiang1
1College of Basic Medical and Sciences, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China.
Aging
|July 30, 2023
概括
精明的孔子是一个明智的孔子.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 系统生物学 系统生物学
背景情况:
- 精明的孔子枕头精液 (SCPE) 是一种广泛使用的东亚传统处方,用于治疗认知障碍 (CI).
- 了解SCPE疗效的分子基础对于其临床应用和开发至关重要.
- 在SCPE对CI的治疗作用的基础上,精确的活性成分和机制仍未完全阐明.
研究的目的:
- 确定SCPE内负责治疗认知障碍的活性成分.
- 为了阐明SCPE针对的特定分子信号通路.
- 在CI的临床前模型中探索SCPE作用的综合分子机制.
主要方法:
- 系统药理方法,包括数据库选和拓分析,用于识别活性成分.
- 使用Python进行了分子对接模拟,以分析组件-目标相互作用.
- 采用了CI的老化加速倾向8 (SAMP8) 鼠标模型,通过水迷宫测试评估认知功能,并通过西方涂抹和微透析研究分子机制.
主要成果:
- 确定了SCPE的30个活性成分,其中23个与PI3K/Akt/mTOR信号通路相互作用.
- 在CI小鼠模型中,SCPE治疗显著改善了认知功能,增加了神经递质5-基胺 (5-HT) 和其代谢物5-基酸 (5-HIAA) 的水平,并减少了神经病理损伤.
- SCPE通过增加关键蛋白质 (p-PI3K,p-Akt,p-mTOR,LC3-II/LC3-I) 的表达和降低海马组织中的P62表达来调节PI3K/Akt/mTOR通路.
结论:
- 在临床前的模型中,SCPE有效地改善了认知障碍.
- SCPE的治疗效果是由其调节PI3K/Akt/mTOR信号通路的活性成分调节的.
- SCPE增强神经递质水平 (5-HT,5-HIAA) 并抑制病理损伤,为认知障碍提供潜在的治疗策略.
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