在记忆任务期间,脑功能连接的变化在患有中风后认知障碍的患者中:一项fNIRS研究
Ying Kong1, Wenna Peng1, Jing Li1
1Department of Rehabilitation, the Second Xiangya Hospital, Central South University, No. 139, Renmin Rd. Furong District, Changsha 410011, Hunan China.
概括
大脑功能连接的减少可能表明中风后的认知障碍. 功能近红外谱学 (fNIRS) 有助于识别这些变化,提供了对中风后认知障碍神经机制的见解.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 认知科学 认知科学
背景情况:
- 卒中幸存者经常经历认知障碍,影响日常生活.
- 了解中风后认知障碍 (PSCI) 的神经机制对于有效治疗至关重要.
- 功能连接 (FC) 改变与各种神经疾病有关.
研究的目的:
- 在PSCI患者的记忆任务中评估大脑区域的功能连接 (FC).
- 使用功能近红外光谱学 (fNIRS) 探索中风后认知障碍背后的神经机制.
- 评估fNIRS在确定中风患者认知缺陷方面的有用性.
主要方法:
- 使用时钟绘图测试,数字跨度测试和Corsi Block-tapping测试评估短期记忆和视觉空间能力.
- 使用fNIRS从双边运动感官皮质和前额叶记录了氧化血红蛋白度信号.
- 在19名PSCI患者,27名中风患者 (STR) 和26名健康对照患者 (HC) 中分析了FC.
主要成果:
- MMSE得分与时钟图和数字跨度测试有正相关.
- 在特定的记忆任务中,PSCI组在双边运动感官皮质和运动感官皮质-前叶之间表现出降低的FC.
- FC水平与迷你心理状态考试 (MMSE) 的分数密切相关.
结论:
- 功能连接性下降可能成为PSCI认知障碍的生物标志物.
- fNIRS提供了一种非侵入性的方法来检测中风后的认知障碍.
- FC变化为中风后认知缺陷的神经支提供了宝贵的见解.
关键词:
认知功能障碍 认知功能障碍认知障碍 认知障碍是一种认知障碍.诊断成像诊断成像的使用功能性近红外光谱学 (fNIRS) 是一种功能性近红外光谱学.功能连接性的功能连接性.脑卒中后的认知障碍 (PSCI)更多相关视频
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